Annals of Toxicology

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Table of Content: Volume 2, Issue 1

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Review Article Pages 36-44

Synthetic Endocrine Disrupting Chemicals are not a Significant Cause of Obesity

Authors: Carr J Smith, Thomas A Perfetti, A Wallace Hayes and Sir Colin Berry

Abstract: Obesity is a worldwide epidemic with approximately two billion adults classifiable as overweight and over 600 million as obese. In the US, approximately two-thirds of adults over age 20 are overweight with about 35% currently obese with the obesity percentage steadily rising.

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Research Article Pages 26-35

Bee Venom Melittin Modulates Phospholipase A2 Activity by Affecting Substrate Interface on the Surface of Phosphatidylcholine Membrane

Authors: Yong Xu, Paul Hanlon, Eppie D Rael and Edward S Gasanoff

Abstract: Melittin is a small amphipathic cationic membrane-active protein in bee venom. Apart from being a key agent in envenomation, melitt in is a physiologically active protein with important pharmacological properties that include anti-cancer and antimicrobial activities. Perhaps melittin’s most important property is its ability to modulate the activity of endogenous phospholipase A2 (PLA2) both in vivo and in vitro.

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Review Article Pages 15-25

Development and Validation of a GC-MS Method for the Simultaneous Quantification of Two Piperazine Designer Drugs Sold in Combination as 'Legal X'

Authors: Patrícia Moreira, MSc, Diana Dias da Silva, PhD, Sara Cunha, PhD, Maria de Lourdes Bastos, PhD and Helena Carmo, PhD

Abstract: 1-Benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl) piperazine (TFMPP) are piperazine drugs of abuse often taken in combination. Considering the frequency of the co-administration of BZP and TFMPP in the clinical, analytical and forensic contexts and its toxicological impact, we aimed to implement a gas chromatography-mass spectrometry (GCMS) technique for the detection and simultaneous quantification of BZP and TFMPP in plasma, urine and cell culture medium.

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Review Article Pages 9-14

Ammi majus an Endemic Medicinal Plant: A Review of the Medicinal Uses, Pharmacological and Phytochemicals

Authors: Mohammad Amzad Hossain and S Al Touby

Abstract: Recently, most of the rural areas people are using alternative medicine for the treatment of diseases because they believe that natural medicine is always safe and economical. In the Gulf region, the Ammi majus (A. majus) is used traditionally as a safe and sustainable herbal medicine to treat various chronic ulcers. A. majus extracts showed significant biological activity such as antiviral

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